TY - JOUR T1 - Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-228135 VL - 12 IS - 3 SP - e228135 AU - Jeremy Chang AU - Jeffrey Tran AU - Dina Kamel AU - Arnab Basu Y1 - 2019/03/01 UR - http://casereports.bmj.com/content/12/3/e228135.abstract N2 - We describe the clinical course of a 64-year-old woman with stage IVa lung adenocarcinoma who presented with over 1 month of fatigue, unintentional weight loss and emesis. She initiated treatment with nivolumab immunotherapy 1 year prior and had been tolerating the treatment well. A comprehensive workup revealed multiple endocrinological abnormalities consistent with hypophysitis leading to hypopituitarism in the form of central adrenal insufficiency and hypogonadism as well as a partially empty sella on imaging. This case demonstrates that while receiving novel forms of treatment such as immunotherapy, patients should be monitored closely for a wide range of adverse effects. ER -