PT - JOURNAL ARTICLE AU - Timothy Shun Him Kwok AU - Mary Jane Bell TI - Immune checkpoint inhibitor-induced rheumatoid arthritis: insights into an increasingly common aetiology of polyarthritis AID - 10.1136/bcr-2018-227995 DP - 2019 Feb 01 TA - BMJ Case Reports PG - e227995 VI - 12 IP - 2 4099 - http://casereports.bmj.com/content/12/2/e227995.short 4100 - http://casereports.bmj.com/content/12/2/e227995.full SO - BMJ Case Reports2019 Feb 01; 12 AB - Nivolumab is an immune checkpoint inhibitor that is used in the treatment of a variety of cancers in the adjuvant or metastatic setting. Adverse effects include non-specific activation of T cells, leading to immune-related adverse events in downstream organs. We present a case of a 36-year-old man with unresectable oropharyngeal squamous cell carcinoma who developed nivolumab-induced rheumatoid arthritis. As immune checkpoint inhibitor use is becoming widespread in the medical oncology domain, the purpose of this case report is to increase awareness of an increasingly common cause of rheumatic disease and to alert clinicians to consider immunotherapy in their differential diagnosis of polyarthritis. This case also highlights the importance of working in an interdisciplinary manner to enhance cancer care for the patient as well as to increase awareness of the potential adverse effects of immunotherapy in patients with cancer.