RT Journal Article SR Electronic T1 Atypical testicular pain JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e226697 DO 10.1136/bcr-2018-226697 VO 12 IS 2 A1 Nishant Bedi A1 Muhammad Naim Che Rahimi A1 Sarah Menzies A1 Jas Kalsi YR 2019 UL http://casereports.bmj.com/content/12/2/e226697.abstract AB Testicular tuberculosis (TB) is rare, and, because of this, the lack of pathognomonic clinical features and its tendency to mimic other commoner conditions, the diagnosis is frequently delayed or may be missed. In this case, the initial clinical presentation was typical for bacterial epididymo-orchitis in a 38-year-old man. When the patient failed to improve with standard treatment including broadening of antibiotics, the diagnosis was re-considered because some unusual signs suggested testicular malignancy or lymphoma. Further, history-taking and subsequent cross-sectional imaging with CT/MRI identified co-existent pulmonary nodularity, thoracic and abdominal lymphadenopathy and bony changes that, together, raised the suspicion of TB. Mycobacterium tuberculosis was confirmed on DNA-based testing of the hydrocele fluid, although standard acid-fast bacilli culture was negative. This case prompted a review of the literature to explore the optimal steps in the investigation and diagnosis of this rare disease.