PT  - JOURNAL ARTICLE
AU  - Subhasish Bose
AU  - Samata Pathireddy
AU  - Krishna M Baradhi
AU  - Narothama Reddy Aeddula
TI  - Alport’s syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship
AID  - 10.1136/bcr-2018-228175
DP  - 2019 Jan 01
TA  - BMJ Case Reports
PG  - e228175
VI  - 12
IP  - 1
4099  - http://casereports.bmj.com/content/12/1/e228175.short
4100  - http://casereports.bmj.com/content/12/1/e228175.full
SO  - BMJ Case Reports2019 Jan 01; 12
AB  - A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport’s syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature.