TY - JOUR T1 - Alport’s syndrome and intracranial aneurysm: mere coincidence or undiscovered causal relationship JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-228175 VL - 12 IS - 1 SP - e228175 AU - Subhasish Bose AU - Samata Pathireddy AU - Krishna M Baradhi AU - Narothama Reddy Aeddula Y1 - 2019/01/01 UR - http://casereports.bmj.com/content/12/1/e228175.abstract N2 - A 44-year-old Caucasian man with a history of deceased donor renal transplant for end-stage renal disease from Alport’s syndrome (AS), presented with a spontaneous subarachnoid haemorrhage and hydrocephalus. Following an external ventricular drain for the hydrocephalus, a CT angiography revealed a dissection of the left vertebral artery extending into vertebro-basilar junction necessitating a bypass between left occipital artery to left posterior inferior cerebellar artery. He had a posterior fossa Craniectomy, C1 laminectomy and coiling off, of the left vertebral artery. Postprocedure course was prolonged but uneventful with complete recovery and normal renal function 18 months postpresentation. AS, a disease caused by abnormalities in the synthesis of type IV collagen, can cause aneurysms with severe and permanent neurological sequalae. We present a case of AS with intracranial arterial dissection with potential life-threatening consequences and discuss the genetic and molecular basis of AS along with review of the relevant literature. ER -