RT Journal Article
SR Electronic
T1 Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e226121
DO 10.1136/bcr-2018-226121
VO 12
IS 1
A1 Tajwar Nasir
A1 Claudia Lee
A1 Alexandra SC Lawrence
A1 Jeremy S Brown
YR 2019
UL http://casereports.bmj.com/content/12/1/e226121.abstract
AB We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA while taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Recognition that TKI treatment may predispose to invasive aspergillosis will allow for rapid recognition of affected patients and more effective management of future cases.