PT  - JOURNAL ARTICLE
AU  - Tajwar Nasir
AU  - Claudia Lee
AU  - Alexandra SC Lawrence
AU  - Jeremy S Brown
TI  - Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors
AID  - 10.1136/bcr-2018-226121
DP  - 2019 Jan 01
TA  - BMJ Case Reports
PG  - e226121
VI  - 12
IP  - 1
4099  - http://casereports.bmj.com/content/12/1/e226121.short
4100  - http://casereports.bmj.com/content/12/1/e226121.full
SO  - BMJ Case Reports2019 Jan 01; 12
AB  - We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA while taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Recognition that TKI treatment may predispose to invasive aspergillosis will allow for rapid recognition of affected patients and more effective management of future cases.