TY - JOUR T1 - Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-226121 VL - 12 IS - 1 SP - e226121 AU - Tajwar Nasir AU - Claudia Lee AU - Alexandra SC Lawrence AU - Jeremy S Brown Y1 - 2019/01/01 UR - http://casereports.bmj.com/content/12/1/e226121.abstract N2 - We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA while taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Recognition that TKI treatment may predispose to invasive aspergillosis will allow for rapid recognition of affected patients and more effective management of future cases. ER -