TY - JOUR T1 - Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-227068 VL - 12 IS - 1 SP - bcr-2018-227068 AU - Marius Vögelin AU - Richard Cathomas AU - Niklaus Kamber AU - Thomas Fehr Y1 - 2019/01/01 UR - http://casereports.bmj.com/content/12/1/bcr-2018-227068.abstract N2 - Two years after diagnosis of a metastatic neuroendocrine gastrin-secreting tumour and after several cycles of chemotherapy and peptide receptor radionuclide therapy, a 56-year-old woman presented with hypokalaemic metabolic alkalosis, hypertension, leg oedema and new-onset diabetes mellitus. Further investigations revealed renal potassium loss confirmed by a transtubular potassium gradient of 16, fully suppressed serum aldosterone, but instead highly elevated blood levels of morning cortisol and adrenocorticotropic hormone as well as increased urinary excretion of glucocorticoid and mineralocorticoid metabolites. Ruling out other causes, paraneoplastic hypercortisolism was diagnosed. Pharmacological inhibition of the steroid 11β-hydroxylase with metyrapone resulted in complete resolution of metabolic alkalosis, hypokalaemia, hypertension, hyperglycaemia and leg oedema within 1 week. ER -