PT  - JOURNAL ARTICLE
AU  - Franco Fulciniti
AU  - Jessica Barizzi
AU  - Pierpaolo Trimboli
AU  - Luca Giovanella
TI  - Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features
AID  - 10.1136/bcr-2018-226153
DP  - 2019 Jan 01
TA  - BMJ Case Reports
PG  - e226153
VI  - 12
IP  - 1
4099  - http://casereports.bmj.com/content/12/1/e226153.short
4100  - http://casereports.bmj.com/content/12/1/e226153.full
SO  - BMJ Case Reports2019 Jan 01; 12
AB  - Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Neoplasms belonging to such category generally carry RET-PTC (REarranged during Transfection- Papillary Thyroid Carcinoma) fusions and seem to have a slightly worse prognosis with respect to classical and follicular variants of papillary thyroid carcinoma (PTC), though consistent prognostic and survival data are scarce. SV-PTC should be differentiated from trabecular-insular poorly differentiated thyroid carcinomas, which occur in a different age group and carry a dismal prognosis. These latter tumours do not show the typical nuclear features of PTC and show tumour necrosis with an high mitotic activity. In this report a further case of SV-PTC is described which was associated to Hashimoto’s thyroiditis, a finding never described in the cytological literature up to now for SV-PTC; this association created further differential diagnostic problems. The neoplasm displayed RET-PTC1 fusion.