PT - JOURNAL ARTICLE AU - Faisal Inayat AU - Asad Ur Rahman AU - Effa Zahid AU - Nouman Safdar Ali AU - Roger Charles TI - Symptomatic involvement of the stomach and duodenum as initial presentation of AL amyloidosis AID - 10.1136/bcr-2018-227550 DP - 2019 Jan 01 TA - BMJ Case Reports PG - bcr-2018-227550 VI - 12 IP - 1 4099 - http://casereports.bmj.com/content/12/1/bcr-2018-227550.short 4100 - http://casereports.bmj.com/content/12/1/bcr-2018-227550.full SO - BMJ Case Reports2019 Jan 01; 12 AB - Primary systemic or amyloid light chain (AL) amyloidosis is a multisystem disorder with myriad presentations. Although it can involve the upper gastrointestinal tract in 8% of cases, symptomatic involvement is exceedingly rare. We chronicle here a case of postprandial epigastric pain associated with AL amyloidosis involving the stomach and duodenum. Pathological examination of endoscopic biopsy using Congo red staining confirmed the diagnosis. In order to establish the underlying aetiology of AL amyloidosis, the patient underwent extensive workup. Eventually, she was diagnosed with multiple myeloma based on the standard set of investigations. This paper underscores the importance of clinical suspicion of amyloidosis in patients presenting with non-specific gastrointestinal symptoms and highlights the role of endoscopic biopsy to confirm the amyloid deposition. Since gastrointestinal amyloidosis is a disease with a poor prognosis, early diagnosis and treatment are particularly warranted.