RT Journal Article
SR Electronic
T1 Large cell neuroendocrine carcinoma of the uterine cervix
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr-2018-225880
DO 10.1136/bcr-2018-225880
VO 12
IS 1
A1 Habeeb, Amir
A1 Habeeb, Hany
YR 2019
UL http://casereports.bmj.com/content/12/1/bcr-2018-225880.abstract
AB We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation—the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.