PT  - JOURNAL ARTICLE
AU  - Habeeb, Amir
AU  - Habeeb, Hany
TI  - Large cell neuroendocrine carcinoma of the uterine cervix
AID  - 10.1136/bcr-2018-225880
DP  - 2019 Jan 01
TA  - BMJ Case Reports
PG  - bcr-2018-225880
VI  - 12
IP  - 1
4099  - http://casereports.bmj.com/content/12/1/bcr-2018-225880.short
4100  - http://casereports.bmj.com/content/12/1/bcr-2018-225880.full
SO  - BMJ Case Reports2019 Jan 01; 12
AB  - We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation—the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.