PT - JOURNAL ARTICLE AU - Courtney L Hanlon AU - Artin Galoosian AU - Saima Ali AU - Randall S Edson TI - Painful rash with hoarseness: an atypical presentation of syphilis AID - 10.1136/bcr-2018-226892 DP - 2018 Nov 01 TA - BMJ Case Reports PG - e226892 VI - 11 IP - 1 4099 - http://casereports.bmj.com/content/11/1/e226892.short 4100 - http://casereports.bmj.com/content/11/1/e226892.full SO - BMJ Case Reports2018 Nov 01; 11 AB - Syphilis is a sexually transmitted disease that can affect multiple organ systems, with central nervous system involvement at any stage. We present a 53-year-old woman with an unusual truncal rash with painful anogenital lesions, accompanied by patchy alopecia, oral lesions, photophobia and hoarseness. She was found to have positive serological tests for syphilis with cerebrospinal fluid findings suggestive of neurosyphilis. She underwent a 14-day course of intravenous penicillin G and exhibited successful resolution of painful anogenital lesions as well as marked improvement in dermatological, oropharyngeal, laryngeal, and neurological symptoms.