RT Journal Article SR Electronic T1 Optic neuritis caused by the re-emerging great masquerader JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e225635 DO 10.1136/bcr-2018-225635 VO 11 IS 1 A1 Nathanial S Nolan A1 Laura E Gibbons A1 Madihah A Hepburn A1 Ahmed Elkeeb A1 Hariharan Regunath YR 2018 UL http://casereports.bmj.com/content/11/1/e225635.abstract AB A 49-year-old Caucasian woman presented with subacute headache and right eye pain associated with scotoma, blurred vision and photophobia. MRI was suggestive of optic neuritis of the right optic nerve and she was treated with steroids. Due to persistent symptoms, a lumbar puncture was performed and cerebrospinal fluid analysis was positive for venereal disease research laboratory and rapid plasma reagin titres. On further history, she recalled experiencing an illness associated with diffuse rash, likely secondary syphilis, 1–2 months prior. She tested negative for HIV. She was treated with intravenous penicillin for 2 weeks following which she experienced improvement in symptoms.