RT Journal Article
SR Electronic
T1 Case of olmesartan-associated enteropathy and transient positive antitissue transglutaminase serology
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e225518
DO 10.1136/bcr-2018-225518
VO 11
IS 1
A1 Jenan Ghaith
A1 Ismail A Raslan
A1 Andrew Szilagyi
A1 Mona Alameldin
YR 2018
UL http://casereports.bmj.com/content/11/1/e225518.abstract
AB Olmesartan-associated enteropathy (OAE) is increasingly being recognised as a major differential diagnosis in patients with villous atrophy and negative coeliac disease (CD) serology. OAE and positive coeliac markers have rarely been reported. We report a case of diarrhoea and small bowel villous blunting associated with a transient elevation of antitissue transglutaminase antibody (ATTG). On discontinuation of olmesartan, symptoms improved, repeat biopsies were normal and levels of ATTG also returned normal. We discuss a possible explanation for the transient elevation in ATTG and the significance of considering OAE/CD overlap.