RT Journal Article SR Electronic T1 Idiopathic hypereosinophilic syndrome with cutaneous involvement: a comparative review of 32 cases JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr-2018-227137 DO 10.1136/bcr-2018-227137 VO 11 IS 1 A1 Faisal Inayat A1 Stacey S O’Neill A1 Fahad Zafar A1 Sindhuja Marupudi A1 Izzah Vasim YR 2018 UL http://casereports.bmj.com/content/11/1/bcr-2018-227137.abstract AB Although idiopathic hypereosinophilic syndrome (HES) is uncommon, we studied the clinical characteristics of this disorder in patients with cutaneous involvement. We chronicle the case of a patient with diffuse skin rash due to idiopathic HES from our clinical experience. Furthermore, a systematic literature search of the medical databases PubMed and Google Scholar was conducted. A total of 32 cases fulfilled the inclusion criteria. The data on patients’ characteristics, epidemiology, clinical features, diagnosis, treatment and outcome were collected and analysed. This review illustrates that physicians should maintain a high index of clinical suspicion for idiopathic HES in patients presenting with dermatological lesions and hypereosinophilia, without an obvious cause. Randomised clinical trials are warranted to outline a generalised and efficient therapeutic approach in these patients. Additionally, this paper highlights the need for population-based studies to delineate the magnitude and scope of this association.