TY - JOUR T1 - Severe haemophilia A in a neonate presenting as haemopneumothorax after tracheo-oesophageal fistula-oesophageal atresia repair JF - BMJ Case Reports DO - 10.1136/bcr-2018-225526 VL - 2018 SP - bcr-2018-225526 AU - Zita Hung AU - Mohammed Bahari AU - Mark J Belletrutti AU - Chloe Joynt Y1 - 2018/11/08 UR - http://casereports.bmj.com/content/2018/bcr-2018-225526.abstract N2 - A male infant with oesophageal atresia and distal tracheo-oesophageal fistula (TEF type C) underwent right thoracotomy and transpleural repair of TEF on day 4 of life. He did not have a family history of coagulation disorders. A preoperative finding of prolonged partial thromboplastin time (PTT)>200 s was overlooked, and he went to surgery. There were no concerns with haemostasis prior to and even during the operation. The prolonged PTT was treated with one 10 mL/kg dose of fresh frozen plasma in the immediate postoperative period. On the fourth postoperative day, the infant developed a right haemopneumothorax, requiring fresh frozen plasma and packed cell transfusions. He was subsequently diagnosed with severe haemophilia A due to intron 22 inversion in the factor VIII gene, with factor VIII level <0.01 IU/mL. ER -