RT Journal Article
SR Electronic
T1 Acquired generalised lipodystrophy and type 1 diabetes mellitus in a child: a rare and implacable association
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr-2018-225553
DO 10.1136/bcr-2018-225553
VO 2018
A1 Rakesh Kumar
A1 Rakesh Kumar Pilania
A1 Anmol Bhatia
A1 Devi Dayal
YR 2018
UL http://casereports.bmj.com/content/2018/bcr-2018-225553.abstract
AB Lipodystrophy syndromes are frequently associated with marked degree of insulin resistance and lipoatrophic diabetes. Although acquired generalised lipodystrophy (AGL) has been known to be associated with various autoimmune disorders, type 1 diabetes mellitus (T1DM) is very rarely reported to occur with AGL. Combination of AGL and T1DM can lead to a totally different phenotype with very difficult-to-treat diabetes and progressive complications of both the conditions. We report a case of AGL with T1DM with poor diabetes control despite high doses of insulin, metformin and pioglitazone. Our case further progressed to develop complication of retroperitoneal fibrosis, not hitherto reported with AGL.