PT - JOURNAL ARTICLE AU - Mariola Smotrys AU - Tara Magge AU - Samer Alkhuja AU - Susheer Dilbagh Gandotra TI - Babesiosis as a cause of false-positive HIV serology AID - 10.1136/bcr-2017-223738 DP - 2018 Jun 08 TA - BMJ Case Reports PG - bcr-2017-223738 VI - 2018 4099 - http://casereports.bmj.com/content/2018/bcr-2017-223738.short 4100 - http://casereports.bmj.com/content/2018/bcr-2017-223738.full AB - This is a case of a 71-year-old homosexual man who presented with a 4-day history of fever, weakness and headaches, near syncope, nausea and poor oral intake. The patient denied recent travel or sick contacts but had significant tick bites in the last 4 weeks. A peripheral blood smear showed 0.5% parasitaemia with signet ring appearance organisms consistent with Babesia microti. Serology testing for HIV 1 and 2 by ELISA and western blot were positive. Treatment for Babesia was started and the patient improved. Repeat serology testing for HIV was negative. To the best of our knowledge, this is the first case of false-positive HIV serology that is associated with active babesiosis. In this case, the positive HIV serology turned negative after successful treatment of babesiosis.