TY - JOUR T1 - Prolonged paralysis with atracurium use in a patient with Rubinstein-Taybi syndrome JF - BMJ Case Reports DO - 10.1136/bcr-2017-222692 VL - 2018 SP - bcr-2017-222692 AU - T Kumaravadivel Dharmalingam AU - Constance Liew Sat Lin AU - Rajesh Kumar Muniandy Y1 - 2018/02/22 UR - http://casereports.bmj.com/content/2018/bcr-2017-222692.abstract N2 - Rubinstein-Taybi syndrome (RTS) is a rare autosomal dominant disorder that occurs due to a microdeletion of chromosome 16p13. The craniofacial abnormalities in these patients may pose a challenge for anaesthetist performing tracheal intubation. However, there are no known reported cases of drug interaction with non-depolarising muscle relaxant in patients with RTS. This young patient with RTS presented with an unexpected prolonged atracurium effect during the course of anaesthesia. After ruling out other possible causes, we have come to a conclusion that RTS itself could have played a role in the prolonged effect of atracurium. However, further studies will be needed to confirm this hypothesis. In the meantime, care should be used when using muscle relaxants in patients with RTS. ER -