RT Journal Article
SR Electronic
T1 Late diagnosis: a case of rapidly progressive extranodal NK/T cell lymphoma, nasal type
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr-2017-221019
DO 10.1136/bcr-2017-221019
VO 2018
A1 Hiroyuki Mori
A1 Kei Ebisawa
A1 Mitsushige Nishimura
A1 Kenji Kanazawa
YR 2018
UL http://casereports.bmj.com/content/2018/bcr-2017-221019.abstract
AB Extranodal natural killer (NK)/T cell lymphoma, nasal type is a condition that has poor prognosis. Accurate diagnosis of lymphoma is made by pathological findings. We report a case of extranodal NK/T cell lymphoma, nasal type affecting the lung and liver and which was difficult to diagnose because of negative biopsy results from multiple sites. A 39-year-old man who had dry cough and fever for 1 month was referred to our hospital. He had pancytopenia and elevated serum levels of lactate dehydrogenase and soluble interleukin-2 receptor. Hepatosplenomegaly and multiple lung nodules were found on imaging study. Specimens of bronchoscopic lung, percutaneous liver, bone marrow and random skin biopsies were all negative. Open lung biopsy was not definitive. Unfortunately, disease progression was rapid and fatal before results of pleural fluid cytology and a second liver biopsy showed extranodal NK/T cell lymphoma, nasal type. This report focused on diagnostic planning for rapidly progressive extranodal NK/T-cell lymphoma, nasal type.