PT  - JOURNAL ARTICLE
AU  - Prabhjot S Bedi
AU  - Manoj P Rai
AU  - Nishant Tageja
AU  - Heather Laird-Fick
TI  - Hepatotoxicity Associated With Vismodegib
AID  - 10.1136/bcr-2017-222969
DP  - 2018 Feb 08
TA  - BMJ Case Reports
PG  - bcr-2017-222969
VI  - 2018
4099  - http://casereports.bmj.com/content/2018/bcr-2017-222969.short
4100  - http://casereports.bmj.com/content/2018/bcr-2017-222969.full
AB  - An 82-year-old Caucasian woman with a history of basal cell carcinoma on vismodegib presented with nausea, vomiting and intermittent abdominal pain. Laboratory results were remarkable for the elevation of liver enzymes. Endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiogram (PTC) did not show evidence of intrahepatic or extrahepatic obstruction of the biliary tract. During PTC external biliary catheter was placed; however, bilirubin continued to rise. Further, laboratory work-up and imaging studies ruled out other possible aetiologies for hepatotoxicity such as infections, autoimmune hepatitis and other drugs known to be hepatotoxic thus leaving vismodegib the most likely cause of hepatotoxicity.