RT Journal Article
SR Electronic
T1 Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr-2017-221840
DO 10.1136/bcr-2017-221840
VO 2018
A1 Karolina Polchlopek Blasiak
A1 Federico Simonetta
A1 Maria-Isabel Vargas
A1 Yves Chalandon
YR 2018
UL http://casereports.bmj.com/content/2018/bcr-2017-221840.abstract
AB A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT.