PT  - JOURNAL ARTICLE
AU  - Karolina Polchlopek Blasiak
AU  - Federico Simonetta
AU  - Maria-Isabel Vargas
AU  - Yves Chalandon
TI  - Central nervous system graft-versus-host disease (CNS-GvHD) after allogeneic haematopoietic stem cell transplantation
AID  - 10.1136/bcr-2017-221840
DP  - 2018 Jan 12
TA  - BMJ Case Reports
PG  - bcr-2017-221840
VI  - 2018
4099  - http://casereports.bmj.com/content/2018/bcr-2017-221840.short
4100  - http://casereports.bmj.com/content/2018/bcr-2017-221840.full
AB  - A 60-year-old man presented with impaired consciousness and psychomotor agitation after a second allogeneic haematopoietic stem cell transplantation (HSCT) from a matched unrelated donor for acute myeloid leukaemia. Clinical, biological and radiological evidence suggested a diagnosis of central nervous system graft-versus-host disease (CNS-GvHD). After intrathecal infusion of methylprednisolone, the clinical symptoms as well as the radiological abnormalities disappeared. The present report illustrates the difficulties in the diagnosis and the management of CNS-GvHD, a very rare and still challenging neurological complication that can occur after allogeneic HSCT.