TY - JOUR T1 - Short-course high-dose ibuprofen causing both early and delayed jejunal perforations in a non-smoking man JF - BMJ Case Reports DO - 10.1136/bcr-2017-223644 VL - 2017 SP - bcr-2017-223644 AU - Aseef Yehiyan AU - Sowrav Barman AU - Haren Varia AU - Stephen Pettit Y1 - 2017/12/20 UR - http://casereports.bmj.com/content/2017/bcr-2017-223644.abstract N2 - A 48-year-old non-smoking man underwent laparotomy for peritonitis immediately after taking ibuprofen 800 mg 6 hourly for 14 days for back pain. His only other medication was long-term omeprazole 20 mg per day. At operation he had three separate perforations in his proximal jejunum. Fifteen centimetres of jejunum were resected with primary anastomosis. Histology showed focal mucosal ischaemic changes with normal mucosa between. There was no vasculitis. The perforations were attributed to ibuprofen intake. He made an uneventful recovery and was instructed to refrain from non-steroidal anti-inflammatory drug (NSAID) intake.He was readmitted … ER -