PT  - JOURNAL ARTICLE
AU  - Gyanendra Acharya
AU  - Maria T Cruz Carreras
AU  - Terry Wynne Rice
TI  - 5-FU-induced leukoencephalopathy with reversible lesion of splenium of corpus callosum in a patient with colorectal cancer
AID  - 10.1136/bcr-2017-222030
DP  - 2017 Nov 21
TA  - BMJ Case Reports
PG  - bcr-2017-222030
VI  - 2017
4099  - http://casereports.bmj.com/content/2017/bcr-2017-222030.short
4100  - http://casereports.bmj.com/content/2017/bcr-2017-222030.full
AB  - 5-Fluorouracil (5-FU), a commonly used antimetabolite and antineoplastic agent, has been approved for treatment of various cancers. Neurotoxicities are considered extremely rare side effects of 5-FU. We present a case of 5-FU-induced encephalopathy with diffusion-restricted reversible lesion of the splenium of the corpus callosum in a patient with colorectal cancer. The patient presented with confusion, dysarthria and agitation after 5-FU infusion. The prognosis of this toxic effects of 5-FU is usually good if recognised and treated in time. Emergency physicians, general practitioners and oncologists should be aware of this rare side effects of 5-FU chemotherapy and its diagnosis and treatment.