PT  - JOURNAL ARTICLE
AU  - Chrystal Chan
AU  - James Mark Roberts
TI  - Ectopic ACTH syndrome complicated by multiple opportunistic infections treated with percutaneous ablation of the adrenal glands
AID  - 10.1136/bcr-2017-221580
DP  - 2017 Nov 14
TA  - BMJ Case Reports
PG  - bcr-2017-221580
VI  - 2017
4099  - http://casereports.bmj.com/content/2017/bcr-2017-221580.short
4100  - http://casereports.bmj.com/content/2017/bcr-2017-221580.full
AB  - Ectopic adrenocorticotropic hormone (ACTH)-related Cushing’s syndrome can lead to multiple complications including severe immunosuppression. If the ACTH-secreting tumour cannot be found, definitive treatment is surgical adrenalectomy, typically followed by glucocorticoid replacement. Here, we present a case of fulminant respiratory failure secondary to coinfection with Pneumocystis jirovecii and cytomegalovirus in a patient with ectopic ACTH-dependent Cushing’s syndrome with occult primary. Due to significant deconditioning, she was unable to undergo definitive adrenalectomy and instead underwent percutaneous microwave ablation of the adrenal glands.