TY - JOUR T1 - Durable complete remission with combination chemotherapy and bortezomib in HIV-associated plasmablastic lymphoma JF - BMJ Case Reports DO - 10.1136/bcr-2017-222063 VL - 2017 SP - bcr-2017-222063 AU - Nivedita Arora AU - Arjun Gupta AU - Navid Sadeghi Y1 - 2017/10/07 UR - http://casereports.bmj.com/content/2017/bcr-2017-222063.abstract N2 - Plasmablastic lymphoma (PBL) is an aggressive form of non-Hodgkin’s lymphoma (NHL) classically seen in patients infected with the human immunodeficiency virus, but can also be seen in other immunocompromised states such as transplant recipients, autoimmune diseases and the elderly. PBL is generally associated with a poor prognosis despite chemotherapy. There is evidence supporting the use of bortezomib in combination with standard chemotherapy to achieve durable responses in patients with PBL. We describe a patient with acquired immunodeficiency syndrome who presented with rectal pain and bright red blood per rectum. He was diagnosed with stage IVA PBL with anorectal, nodal, calvarial and hepatic involvement. Along with highly active antiretroviral therapy, he was treated with six cycles of dose adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH) plus bortezomib resulting in durable complete remission 30 months after diagnosis. ER -