PT  - JOURNAL ARTICLE
AU  - Pang, Nicholas Tze Ping
AU  - Mohamad Isa, Mohd Fadzli
AU  - Suarn Singh, Vikram
AU  - Masiran, Ruziana
TI  - Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome
AID  - 10.1136/bcr-2017-221048
DP  - 2017 Jul 27
TA  - BMJ Case Reports
PG  - bcr-2017-221048
VI  - 2017
4099  - http://casereports.bmj.com/content/2017/bcr-2017-221048.short
4100  - http://casereports.bmj.com/content/2017/bcr-2017-221048.full
AB  - A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due to treatment resistance, adherence and functionality were poor and there was still persistent drug use. As a result, a long acting injectable adjunct was commenced, but only minimal effects were observed. However after initiation of directly observed treatment of clozapine with methadone, there has been functional and clinical response and drug use has ceased.