RT Journal Article
SR Electronic
T1 Metaplastic breast carcinoma with chondroid differentiation: a rare variant of infiltrative carcinoma in a 38-year-old woman
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr-2016-217687
DO 10.1136/bcr-2016-217687
VO 2017
A1 Shokouh Taghipour Zahir
A1 Mostafa Javannejad
YR 2017
UL http://casereports.bmj.com/content/2017/bcr-2016-217687.abstract
AB Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen. Both carcinomatous and chondroid cells exhibited p53 overexpression. Sentinel lymph node biopsy revealed no tumorous involvement.