RT Journal Article SR Electronic T1 Duodenal variceal bleed: an unusual cause of upper gastrointestinal bleed and a difficult diagnosis to make JF BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr2016218669 DO 10.1136/bcr-2016-218669 VO 2017 A1 Bhagani, Shradha A1 Winters, Conchubhair A1 Moreea, Sulleman YR 2017 UL http://casereports.bmj.com/content/2017/bcr-2016-218669.abstract AB We present a case of recurrent upper gastrointestinal (GI) bleeding in a man aged 57 years with primary biliary cholangitis who was ultimately diagnosed with an isolated duodenal variceal bleed, which was successfully treated with histoacryl glue injection. Duodenal varices are an uncommon presentation of portal hypertension and can result in significant GI bleeding with a high mortality. Diagnosis can be difficult and therapeutic options limited. Endoscopic variceal sclerotherapy with histoacryl glue provides an effective treatment, though endoscopists need to remain aware of and vigilant for the serious complications of this treatment option.