PT - JOURNAL ARTICLE AU - Yuki Kirito AU - Daisuke Yamamoto AU - Tsuyoshi Uchiyama TI - Proteinase 3-antineutrophil cytoplasmic antibody-positive ulcerative colitis presenting with abducens neuropathy AID - 10.1136/bcr-2016-218353 DP - 2017 Jan 09 TA - BMJ Case Reports PG - bcr2016218353 VI - 2017 4099 - http://casereports.bmj.com/content/2017/bcr-2016-218353.short 4100 - http://casereports.bmj.com/content/2017/bcr-2016-218353.full AB - A 72-year-old man with ulcerative colitis (UC) presented with complete left abducens nerve palsy. Although MRI showed no significant changes, cerebrospinal fluid analysis revealed pleocytosis and elevated protein and interleukin (IL)-6 levels. His serum proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) level was also elevated to 31.1 U/mL, but granulomatosis with polyangiitis was not observed. On the basis of the diagnosis of autoimmune cranial neuropathy, he was treated with steroid therapy. While tapering steroid therapy, his serum PR3-ANCA levels; cerebrospinal fluid findings, including IL-6 levels; and symptoms improved. Serum PR3-ANCA could be a useful parameter of neurological disorders associated with ANCA-positive UC.