RT Journal Article
SR Electronic
T1 Aspirin unmasking acquired haemophilia A in a patient with prostate cancer
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr2016216890
DO 10.1136/bcr-2016-216890
VO 2016
A1 Julie Omolola Okiro
A1 Amjad Zaman Khan
A1 Fergus Keane
A1 Faiza Murad
YR 2016
UL http://casereports.bmj.com/content/2016/bcr-2016-216890.abstract
AB A 72-year-old man, on treatment for prostate cancer, attended the emergency department with his 2nd episode of spontaneous extensive bruising and haematomas. His first presentation was 2 months prior but this was thought to be because of his aspirin and he improved when aspirin was discontinued. On this occasion aspirin had been restarted 7 days before he developed his symptoms. His blood investigation was significant for a much raised activated partial thromboplastin time (aPTT). On his 3rd day of admission he deteriorated clinically with a drastic drop in his haemoglobin and worsening tense haematomas. Blood investigations confirmed the diagnosis of acquired factor VIII deficiency and he subsequently received treatment with factor VIII inhibitor bypassing activity, steroids and immunosuppresants.