TY - JOUR T1 - Histological transformation from non-small cell to small cell lung carcinoma JF - BMJ Case Reports DO - 10.1136/bcr-2016-216232 VL - 2016 SP - bcr2016216232 AU - Yuki Haruta(Inoue) AU - Yuki Kataoka AU - Junichi Nikaido AU - Naoki Nakajima Y1 - 2016/08/19 UR - http://casereports.bmj.com/content/2016/bcr-2016-216232.abstract N2 - A 58-year-old woman with no history of smoking was admitted to our hospital with exacerbation of cough. CT of the chest revealed a left upper lobe lung tumour. Bronchoscopic biopsy of the tumour revealed stage IV poorly differentiated adenocarcinoma (figure 1) with epidermal growth factor receptor (EGFR) gene mutation (L858R point mutation). After cytotoxic chemotherapy (cisplatin and pemetrexed) as first-line therapy, disease progression was identified. For … ER -