TY - JOUR T1 - Rapidly progressive coronary artery disease as the first manifestation of antiphospholipid syndrome JF - BMJ Case Reports DO - 10.1136/bcr-2013-203499 VL - 2014 SP - bcr2013203499 AU - Abdullah Sayied Abdullah AU - Hatim Yagoub AU - Thomas J Kiernan AU - Caroline Daly Y1 - 2014/04/08 UR - http://casereports.bmj.com/content/2014/bcr-2013-203499.abstract N2 - Antiphospholipid syndrome (APS) is an autoimmune multisystem disorder characterised by high incidence of arterial and venous thrombosis. Cardiovascular manifestations also include valvular heart disease, ventricular thrombi and higher risk for coronary artery disease (CAD). In this case report, we describe a 61-year-old woman who had no significant risk factors for CAD, and presented with aggressive disease in native and graft vessels that required multiple coronary interventions. The extent of her aggressive CAD could not be explained by her risk factors profile. Therefore autoantibodies screening was carried out and showed a strongly positive anticardiolipin and β2 glycoprotein-I antibody, and hence a diagnosis of antiphospholipid syndrome was made. ER -