PT  - JOURNAL ARTICLE
AU  - Abdullah Sayied Abdullah
AU  - Hatim Yagoub
AU  - Thomas J Kiernan
AU  - Caroline Daly
TI  - Rapidly progressive coronary artery disease as the first manifestation of antiphospholipid syndrome
AID  - 10.1136/bcr-2013-203499
DP  - 2014 Apr 08
TA  - BMJ Case Reports
PG  - bcr2013203499
VI  - 2014
4099  - http://casereports.bmj.com/content/2014/bcr-2013-203499.short
4100  - http://casereports.bmj.com/content/2014/bcr-2013-203499.full
AB  - Antiphospholipid syndrome (APS) is an autoimmune multisystem disorder characterised by high incidence of arterial and venous thrombosis. Cardiovascular manifestations also include valvular heart disease, ventricular thrombi and higher risk for coronary artery disease (CAD). In this case report, we describe a 61-year-old woman who had no significant risk factors for CAD, and presented with aggressive disease in native and graft vessels that required multiple coronary interventions. The extent of her aggressive CAD could not be explained by her risk factors profile. Therefore autoantibodies screening was carried out and showed a strongly positive anticardiolipin and β2 glycoprotein-I antibody, and hence a diagnosis of antiphospholipid syndrome was made.