RT Journal Article
SR Electronic
T1 Limiting progressive hippocampal metabolic abnormalities after smoke inhalation injury
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr2013202157
DO 10.1136/bcr-2013-202157
VO 2014
A1 Edward Tobe
A1 Basant K Pradhan
YR 2014
UL http://casereports.bmj.com/content/2014/bcr-2013-202157.abstract
AB A 46-year-old man had a smoke inhalation injury. Within 1 month, he developed neuropsychiatric problems including toxic encephalopathy, cognitive disorder, depression symptoms and personality change. From 3 to 14 years after the toxic inhalation injury, the patient received treatment with sertraline and methylphenidate. The 18F-fluorodeoxyglucose positron emission tomography scan at 3 years after injury showed deterioration of glucose metabolism in the hippocampus and orbital frontal region; at 14 years after injury, the hippocampus had no significant change but the orbital frontal region had deterioration of glucose metabolism. It was hypothesised that sertraline may have provided selective hippocampal neuroprotection. Further study is justified to evaluate sertraline as a possible neuroprotective agent after smoke inhalation injury.