TY - JOUR T1 - Limiting progressive hippocampal metabolic abnormalities after smoke inhalation injury JF - BMJ Case Reports DO - 10.1136/bcr-2013-202157 VL - 2014 SP - bcr2013202157 AU - Edward Tobe AU - Basant K Pradhan Y1 - 2014/02/27 UR - http://casereports.bmj.com/content/2014/bcr-2013-202157.abstract N2 - A 46-year-old man had a smoke inhalation injury. Within 1 month, he developed neuropsychiatric problems including toxic encephalopathy, cognitive disorder, depression symptoms and personality change. From 3 to 14 years after the toxic inhalation injury, the patient received treatment with sertraline and methylphenidate. The 18F-fluorodeoxyglucose positron emission tomography scan at 3 years after injury showed deterioration of glucose metabolism in the hippocampus and orbital frontal region; at 14 years after injury, the hippocampus had no significant change but the orbital frontal region had deterioration of glucose metabolism. It was hypothesised that sertraline may have provided selective hippocampal neuroprotection. Further study is justified to evaluate sertraline as a possible neuroprotective agent after smoke inhalation injury. ER -