RT Journal Article
SR Electronic
T1 Doxycycline and suicidality
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr2013200723
DO 10.1136/bcr-2013-200723
VO 2013
A1 Atigari, Onome Victor
A1 Hogan, Carys
A1 Healy, David
YR 2013
UL http://casereports.bmj.com/content/2013/bcr-2013-200723.abstract
AB A case series outlining three young individuals with no history of mental disorder who were treated for skin conditions with doxycycline, but developed suicidal ideation with an outcome of suicide in two of the cases. One of these individuals had CYP2C19*2 heterozygote genotype associated with a diminished cytochrome p450 enzyme activity and two of his siblings had developed severe anxiety previously while on doxycycline. Another had previously developed mood difficulties on a lower dose of doxycycline which resolved after discontinuation. In the third individual, a discontinuation of doxycycline has led to the resolution of symptoms without the need for psychotropic medications.