RT Journal Article SR Electronic T1 Steroid-responsive depression JF BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr2013009101 DO 10.1136/bcr-2013-009101 VO 2013 A1 Claus Normann A1 Lukas Frase A1 Mathias Berger A1 Christoph Nissen YR 2013 UL http://casereports.bmj.com/content/2013/bcr-2013-009101.abstract AB A 48-year-old man presented with long-standing symptoms of major depression in the absence of markedly abnormal neurological findings or structural brain alterations. Antidepressive treatment, including medication and psychotherapy, had not led to significant improvement. The EEG, cerebrospinal fluid (CSF) analysis, fluorodeoxyglucose-positron emission tomography and neuropsychological testing showed pathological findings. An epileptic state provided further evidence for an organic encephalopathy. Extensively elevated thyroid-antibodies in the serum and CSF, as well as the rapid and sustained recovery after intravenous treatment with prednisolone, pointed to the diagnosis of a primarily psychiatric manifestation of a steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT).