TY - JOUR T1 - Anaphylaxis to ibuprofen in a 12-year-old boy JF - BMJ Case Reports DO - 10.1136/bcr-2012-007873 VL - 2013 SP - bcr2012007873 AU - Emily Kay AU - Moshe Ben-Shoshan Y1 - 2013/01/14 UR - http://casereports.bmj.com/content/2013/bcr-2012-007873.abstract N2 - Non-steroidal anti-inflammatory (NSAIDs) drugs are a group of medications acting through cyclooxygenase  (COX-1) and cyclooxygenase  (COX-2) enzymes inhibition. Hypersensitivity reactions to NSAIDs, although not rare, are poorly characterised and often go undiagnosed especially in children. We present in this paper a case of ibuprofen anaphylaxis that exemplifies the challenges involved in diagnosis and management of hypersensitivity reactions to NSAIDs. ER -