PT  - JOURNAL ARTICLE
AU  - Emily Kay
AU  - Moshe Ben-Shoshan
TI  - Anaphylaxis to ibuprofen in a 12-year-old boy
AID  - 10.1136/bcr-2012-007873
DP  - 2013 Jan 14
TA  - BMJ Case Reports
PG  - bcr2012007873
VI  - 2013
4099  - http://casereports.bmj.com/content/2013/bcr-2012-007873.short
4100  - http://casereports.bmj.com/content/2013/bcr-2012-007873.full
AB  - Non-steroidal anti-inflammatory (NSAIDs) drugs are a group of medications acting through cyclooxygenase  (COX-1) and cyclooxygenase  (COX-2) enzymes inhibition. Hypersensitivity reactions to NSAIDs, although not rare, are poorly characterised and often go undiagnosed especially in children. We present in this paper a case of ibuprofen anaphylaxis that exemplifies the challenges involved in diagnosis and management of hypersensitivity reactions to NSAIDs.