TY - JOUR T1 - Breast angiosarcoma secondary to phyllodes tumour JF - BMJ Case Reports DO - 10.1136/bcr-2012-007545 VL - 2012 SP - bcr2012007545 AU - Sílvia Costa AU - Susana Alexandra Rodrigues Graça AU - António Ferreira AU - Jorge Maciel Y1 - 2012/12/03 UR - http://casereports.bmj.com/content/2012/bcr-2012-007545.abstract N2 - Angiosarcomas are rare malignant tumours that arise from endothelial cells lining vascular channels, representing 0.04% of malignant neoplasms of the breast. Breast angiosarcomas (BAs) were first described by Schmidt in 1887, and may be primary or secondary to the pre-existing conditions. Primary BAs are more common in young women and present as a palpable mass. Secondary BAs arise in older patients, frequently 5–6 years after radiotherapy, and present as a rash.The authors describe the case of an 83-year-old woman with no history of thoracic radiotherapy or surgery. She had been observed for a breast nodule where biopsy revealed phyllodes tumour. The patient refused surgery and returned 2 years later because of an impressive increase in tumour volume and skin ulceration. She underwent mastectomy with local skin flaps. Histopathological result revealed high-grade angiosarcoma of 15×12 cm. There was follow-up without evidence of recurrence, after radiotherapy. ER -