PT  - JOURNAL ARTICLE
AU  - Yu-Min Feng
AU  - Chin-Wen Feng
AU  - Solomon Chih-Cheng Chen
AU  - Cheng-Da Hsu
TI  - Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: report of two cases and a preliminary HCC cell line study
AID  - 10.1136/bcr-2012-007180
DP  - 2012 Oct 16
TA  - BMJ Case Reports
PG  - bcr2012007180
VI  - 2012
4099  - http://casereports.bmj.com/content/2012/bcr-2012-007180.short
4100  - http://casereports.bmj.com/content/2012/bcr-2012-007180.full
AB  - We reported two cases of hepatocellular carcinoma (HCC) with lung metastases who were treated with a combination of thalidomide and cyproheptadine. The use of cyproheptadine in these two cases was originally for skin itching. Follow-up CT images revealed a complete remission of HCC in both of them after treatment for 6 months and 6 weeks, respectively. A following experimental cell line study demonstrated that cyproheptadine effectively reduced the viability of two HCC cell lines.