RT Journal Article SR Electronic T1 Evolution of certain typical and atypical features in a case of subacute sclerosing panencephalitis JF BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr2012007052 DO 10.1136/bcr-2012-007052 VO 2012 A1 Tushar Premraj Raut A1 Maneesh Kumar Singh A1 Ravindra Kumar Garg A1 Dheeraj Rai YR 2012 UL http://casereports.bmj.com/content/2012/bcr-2012-007052.abstract AB Subacute sclerosing panencephalitis (SSPE) is a slowly progressive inflammatory disease of the central nervous system caused by a persistent measles virus usually affecting the childhood and adolescent age group. Clinical features at onset are very subtle and non-specific. Certain atypical features can occur at onset or during the course of illness which can be misleading. Neuroimaging features often are non-specific. Features like myoclonic jerks, cognitive decline and typical EEG findings lead to a strong suspicion of SSPE. Here, we describe the stagewise progression of a case of SSPE in a 14-year-old girl who had myoclonic jerks and cognitive decline at onset. During the course of disease, the patient developed cortical vision loss, atypical extrapyramidal features like segmental and hemifacial dystonia ultimately leading to a bedbound vegetative state. EEG showed typical periodic discharges along with positive cerebrospinal fluid serology for measles.