RT Journal Article
SR Electronic
T1 Successful treatment of multicentric Castleman's disease accompanying myeloma with bortezomib
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr2012007646
DO 10.1136/bcr-2012-007646
VO 2012
A1 Afaq Ahmad Khan
A1 Fouzia Siraj
A1 Manorama Bhargava
A1 Shyam Aggarwal
YR 2012
UL http://casereports.bmj.com/content/2012/bcr-2012-007646.abstract
AB Castleman's disease represents an atypical lymphoproliferative disorder which is non-clonal but can turn malignant in the form of lymphoma, Kaposi's sarcoma or plasma cell dyscrasia. It has been reported in association with diseases like polyneuropathy organomegaly endocrinopathy monoclonal gammopathy skin changes syndrome and myeloma and very rarely it can be associated with cutaneous vasculitis as in our case. It relatively runs an aggressive course and has a shorter survival. No standard of care therapy is yet established for multicentric Castleman's disease accompanying myeloma. We successfully treated one such patient with bortezomib-based therapy.