TY - JOUR T1 - Ichthyosis prematurity syndrome with separation of fetal membranes and neonatal asphyxia JF - BMJ Case Reports DO - 10.1136/bcr.02.2012.5823 VL - 2012 SP - bcr0220125823 AU - Kristjan Dereksson AU - Sveinn Kjartansson AU - Hulda Hjartardóttir AU - Reynir Arngrimsson Y1 - 2012/08/27 UR - http://casereports.bmj.com/content/2012/bcr.02.2012.5823.abstract N2 - Ichthyosis prematurity syndrome (IPS) is a rare inherited skin disorder. Children are born prematurely with thick skin and have been found to develop neonatal asphyxia due to occlusions in the bronchial tree from debris in the amniotic fluid. At 31 weeks of gestation, separation of amniotic and chorionic membranes was identified as well as polyhydramnion. The child was born 2 weeks later, with thickened skin with a granular appearance and required immediate ventilation and intensive care. At 2 years of age, the patient has developed an atopic skin condition with severe itching, recurrent skin infections, food intolerance and periods of wheezing. Prenatal observation of separation of foetal membranes or dense amniotic fluid may be signs of IPS and severe complication immediately after birth. ER -