RT Journal Article SR Electronic T1 Sepsis, meningitis and cerebral abscesses caused by Citrobacter koseri JF BMJ Case Reports FD BMJ Publishing Group Ltd SP bcr1020114941 DO 10.1136/bcr.10.2011.4941 VO 2012 A1 Clara Vaz Marecos A1 Marta Ferreira A1 Maria Manuela Ferreira A1 Maria Rosalina Barroso YR 2012 UL http://casereports.bmj.com/content/2012/bcr.10.2011.4941.abstract AB After a 36-week diamniotic dichorionic gestation, an infant was delivered by elective caesarean section due to growth restriction and altered diastolic flow in the umbilical artery. Birth weight was 2140 g. The patient was admitted for exclusive parenteral nutrition, with umbilical venous catheter placement. Sinus tachycardia and temperature instability with positive inflammatory markers occurred at 51 h. Penicillin and gentamicin were started, but 6 h later septic shock with disseminated intravascular coagulation was noted. Vancomycin and meropenem were started and penicillin suspended. Citrobacter koseri was isolated from blood culture. Generalised clonic convulsions occurred on day 4, and an electroencephalogram revealed severe encephalic dysfunction. Cerebrospinal fluid cytochemical analysis was suggestive of meningitis, although culture was negative. Cefotaxime was added to the drug regimen. Cranioencephalic MR showed a temporal abscess and diffuse hemispheric destruction, with no indications for neurosurgery. After 6 weeks of therapy, neuroimaging follow-up showed multiloculated cystic encephalomalacia. Currently, the patient is 14 months old with axial hypotonia and decreased movements. The source of infection has not been determined. Nosocomial infection cannot be excluded and vertical transmission is unlikely.