RT Journal Article
SR Electronic
T1 Probable hepatotoxicity associated with the use of metformin in type 2 diabetes
JF BMJ Case Reports
FD BMJ Publishing Group Ltd
SP bcr0420114092
DO 10.1136/bcr.04.2011.4092
VO 2011
A1 Taqi Hashmi
YR 2011
UL http://casereports.bmj.com/content/2011/bcr.04.2011.4092.abstract
AB This is a case report of a 44-year-old obese female who developed subclinical hepatic injury 4 weeks after starting metformin for type 2 diabetes. She had a rise in her alanine aminotransferase which peaked at 5 months (738 U/l) and rapidly declined within days of discontinuing her metformin. No other positive evidence of alternative causes for the hepatic injury was found. The likelihood of metformin-induced injury was 7 on the Naranjo scale of adverse drug reactions. A brief review of the 11 previously reported cases in the English medical literature is also made.